特異性及び抗原分布

ヒトc-kit遺伝子産物(分子量145kDa)と特異的に反応する。c-kit遺伝子産物はSCF(Stem cell Factor)のレセプターであり、結合することにより未分化造血前駆細胞の増殖と分化、肥満細胞の増殖誘導、メラノサイトや生殖細胞の移動や分化が認められる。c-kit遺伝子産物は、肥満細胞やCajalの介在細胞(Interstitial cells of Cajal；ICCs)由来と考えられている消化管のGIST (Gastrointestinal stromal tumor)、精上皮腫/未分化胚細胞腫や肥満細胞由来腫瘍の大部分および悪性黒色腫や肺癌の一部などで発現がみられる。正常では、肥満細胞や精細管、乳管上皮、胃の壁細胞、神経膠細胞、メラノサイトの一部に発現がみられる。

文献

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